Targeted Knockdown of RNA-Binding Protein TIAR for Promoting Self-Renewal and Attenuating Differentiation of Mouse Embryonic Stem Cells

Targeted Knockdown of RNA-Binding Protein TIAR for Promoting Self-Renewal and Attenuating Differentiation of Mouse Embryonic Stem Cells

RNA-binding protein TIAR has been suggested to mediate the translational silencing of ARE-containing mRNAs. To analyze the functions of TIAR, we established RNAi and genetic rescue assays. We evaluated the expression of neuroectoderm markers Pax6 and nestin, mesoderm markers brachyury and Flk1, and...

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Bibliographic Details
Main Authors:	Zhe Geng, Ping Li, Li Tan, Houyan Song
Format:	Article
Language:	English
Published:	Hindawi Limited 2015-01-01
Series:	Stem Cells International
Online Access:	http://dx.doi.org/10.1155/2015/657325

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