Primary adenocarcinoma of the orbit initially diagnosed as idiopathic sclerosing orbital inflammation

Purpose: Differentiating idiopathic sclerosing orbital inflammation from orbital inflammation secondary to neoplasia may be challenging, as both processes can present similarly. Neoplasms in the orbit may induce inflammation with accompanying fibrosis. Limited sections of histopathological specimens...

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Main Authors:	Donovan Reed, Aditya Mehta, Bartlett Hayes, Matthew Caldwell, Frank Scribbick, Brett Davies
Format:	Article
Language:	English
Published:	Elsevier 2019-12-01
Series:	American Journal of Ophthalmology Case Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2451993618304560

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spelling	doaj-4cadf95fb9214adca452d3d4c191cf512020-11-25T01:13:35ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362019-12-0116Primary adenocarcinoma of the orbit initially diagnosed as idiopathic sclerosing orbital inflammationDonovan Reed0Aditya Mehta1Bartlett Hayes2Matthew Caldwell3Frank Scribbick4Brett Davies5Brooke Army Medical Center, 3351 Roger Brooke Drive, Fort Sam Houston, Texas, USA; Corresponding author. 10710 Cedar Elm Drive, San Antonio, TX, 78230.Brooke Army Medical Center, 3351 Roger Brooke Drive, Fort Sam Houston, Texas, USABrooke Army Medical Center, 3351 Roger Brooke Drive, Fort Sam Houston, Texas, USABrooke Army Medical Center, 3351 Roger Brooke Drive, Fort Sam Houston, Texas, USAUniversity of Texas Health Science Center at San Antonio, Texas, USABrooke Army Medical Center, 3351 Roger Brooke Drive, Fort Sam Houston, Texas, USAPurpose: Differentiating idiopathic sclerosing orbital inflammation from orbital inflammation secondary to neoplasia may be challenging, as both processes can present similarly. Neoplasms in the orbit may induce inflammation with accompanying fibrosis. Limited sections of histopathological specimens may demonstrate nonspecific inflammation and lead to an inaccurate diagnosis. Observations: The authors present a case of infiltrating adenocarcinoma of the orbit with mucinous features which was misdiagnosed as idiopathic sclerosing orbital inflammation due to three separate benign biopsy specimens. Conclusions and Importance: The ophthalmologist must remain suspicious of malignancy in cases of suspected idiopathic orbital inflammation with an atypical clinical course, regardless of apparently benign biopsy results. Keywords: Idiopathic orbital inflammation, Orbital adenocarcinoma, Idiopathic sclerosing orbital inflammationhttp://www.sciencedirect.com/science/article/pii/S2451993618304560
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Donovan Reed Aditya Mehta Bartlett Hayes Matthew Caldwell Frank Scribbick Brett Davies
spellingShingle	Donovan Reed Aditya Mehta Bartlett Hayes Matthew Caldwell Frank Scribbick Brett Davies Primary adenocarcinoma of the orbit initially diagnosed as idiopathic sclerosing orbital inflammation American Journal of Ophthalmology Case Reports
author_facet	Donovan Reed Aditya Mehta Bartlett Hayes Matthew Caldwell Frank Scribbick Brett Davies
author_sort	Donovan Reed
title	Primary adenocarcinoma of the orbit initially diagnosed as idiopathic sclerosing orbital inflammation
title_short	Primary adenocarcinoma of the orbit initially diagnosed as idiopathic sclerosing orbital inflammation
title_full	Primary adenocarcinoma of the orbit initially diagnosed as idiopathic sclerosing orbital inflammation
title_fullStr	Primary adenocarcinoma of the orbit initially diagnosed as idiopathic sclerosing orbital inflammation
title_full_unstemmed	Primary adenocarcinoma of the orbit initially diagnosed as idiopathic sclerosing orbital inflammation
title_sort	primary adenocarcinoma of the orbit initially diagnosed as idiopathic sclerosing orbital inflammation
publisher	Elsevier
series	American Journal of Ophthalmology Case Reports
issn	2451-9936
publishDate	2019-12-01
description	Purpose: Differentiating idiopathic sclerosing orbital inflammation from orbital inflammation secondary to neoplasia may be challenging, as both processes can present similarly. Neoplasms in the orbit may induce inflammation with accompanying fibrosis. Limited sections of histopathological specimens may demonstrate nonspecific inflammation and lead to an inaccurate diagnosis. Observations: The authors present a case of infiltrating adenocarcinoma of the orbit with mucinous features which was misdiagnosed as idiopathic sclerosing orbital inflammation due to three separate benign biopsy specimens. Conclusions and Importance: The ophthalmologist must remain suspicious of malignancy in cases of suspected idiopathic orbital inflammation with an atypical clinical course, regardless of apparently benign biopsy results. Keywords: Idiopathic orbital inflammation, Orbital adenocarcinoma, Idiopathic sclerosing orbital inflammation
url	http://www.sciencedirect.com/science/article/pii/S2451993618304560
work_keys_str_mv	AT donovanreed primaryadenocarcinomaoftheorbitinitiallydiagnosedasidiopathicsclerosingorbitalinflammation AT adityamehta primaryadenocarcinomaoftheorbitinitiallydiagnosedasidiopathicsclerosingorbitalinflammation AT bartletthayes primaryadenocarcinomaoftheorbitinitiallydiagnosedasidiopathicsclerosingorbitalinflammation AT matthewcaldwell primaryadenocarcinomaoftheorbitinitiallydiagnosedasidiopathicsclerosingorbitalinflammation AT frankscribbick primaryadenocarcinomaoftheorbitinitiallydiagnosedasidiopathicsclerosingorbitalinflammation AT brettdavies primaryadenocarcinomaoftheorbitinitiallydiagnosedasidiopathicsclerosingorbitalinflammation
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Primary adenocarcinoma of the orbit initially diagnosed as idiopathic sclerosing orbital inflammation

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