Diverse genetic error modes constrain large-scale bio-based production

The declining performance of scale-up bioreactor cultures is commonly attributed to phenotypic and physical heterogeneities. Here, the authors reveal multiple recurring intra-pathway error modes that limit engineered E. coli mevalonic acid production over time- and industrial-scale fermentations.

Bibliographic Details
Main Authors:	Peter Rugbjerg, Nils Myling-Petersen, Andreas Porse, Kira Sarup-Lytzen, Morten O. A. Sommer
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-03232-w

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spelling	doaj-4caa8177d5ef40bd92bbb5f435868dd72021-05-11T09:46:36ZengNature Publishing GroupNature Communications2041-17232018-02-019111410.1038/s41467-018-03232-wDiverse genetic error modes constrain large-scale bio-based productionPeter Rugbjerg0Nils Myling-Petersen1Andreas Porse2Kira Sarup-Lytzen3Morten O. A. Sommer4The Novo Nordisk Foundation Center for Biosustainability, Technical University of DenmarkThe Novo Nordisk Foundation Center for Biosustainability, Technical University of DenmarkThe Novo Nordisk Foundation Center for Biosustainability, Technical University of DenmarkThe Novo Nordisk Foundation Center for Biosustainability, Technical University of DenmarkThe Novo Nordisk Foundation Center for Biosustainability, Technical University of DenmarkThe declining performance of scale-up bioreactor cultures is commonly attributed to phenotypic and physical heterogeneities. Here, the authors reveal multiple recurring intra-pathway error modes that limit engineered E. coli mevalonic acid production over time- and industrial-scale fermentations.https://doi.org/10.1038/s41467-018-03232-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Peter Rugbjerg Nils Myling-Petersen Andreas Porse Kira Sarup-Lytzen Morten O. A. Sommer
spellingShingle	Peter Rugbjerg Nils Myling-Petersen Andreas Porse Kira Sarup-Lytzen Morten O. A. Sommer Diverse genetic error modes constrain large-scale bio-based production Nature Communications
author_facet	Peter Rugbjerg Nils Myling-Petersen Andreas Porse Kira Sarup-Lytzen Morten O. A. Sommer
author_sort	Peter Rugbjerg
title	Diverse genetic error modes constrain large-scale bio-based production
title_short	Diverse genetic error modes constrain large-scale bio-based production
title_full	Diverse genetic error modes constrain large-scale bio-based production
title_fullStr	Diverse genetic error modes constrain large-scale bio-based production
title_full_unstemmed	Diverse genetic error modes constrain large-scale bio-based production
title_sort	diverse genetic error modes constrain large-scale bio-based production
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-02-01
description	The declining performance of scale-up bioreactor cultures is commonly attributed to phenotypic and physical heterogeneities. Here, the authors reveal multiple recurring intra-pathway error modes that limit engineered E. coli mevalonic acid production over time- and industrial-scale fermentations.
url	https://doi.org/10.1038/s41467-018-03232-w
work_keys_str_mv	AT peterrugbjerg diversegeneticerrormodesconstrainlargescalebiobasedproduction AT nilsmylingpetersen diversegeneticerrormodesconstrainlargescalebiobasedproduction AT andreasporse diversegeneticerrormodesconstrainlargescalebiobasedproduction AT kirasaruplytzen diversegeneticerrormodesconstrainlargescalebiobasedproduction AT mortenoasommer diversegeneticerrormodesconstrainlargescalebiobasedproduction
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Diverse genetic error modes constrain large-scale bio-based production

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