Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway

Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway

Alzheimer's disease (AD) is characterized by accumulation and deposition of Aβ peptides in the brain. Aβ deposition in cerebral vessels occurs in many AD patients and results in cerebral amyloid angiopathy (AD/CAA). Aβ deposits evoke neuro- and neurovascular inflammation contributing to neurode...

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Bibliographic Details
Main Authors: Vanja Vukic, Debbie Callaghan, Douglas Walker, Lih-Fen Lue, Qing Yan Liu, Pierre-Oliver Couraud, Ignacio A. Romero, Babette Weksler, Danica B. Stanimirovic, Wandong Zhang
Format: Article
Language:English
Published: Elsevier 2009-04-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Aβ peptides
Brain endothelial cells
Inflammatory gene expression
Signaling pathway
JNK-AP1
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108003185

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