Synthesis, Cyclooxygenases Inhibition Activities and Interactions with BSA of <i>N</i>-substituted 1<i>H</i>-pyrrolo[3,4-c]pyridine-1,3(<i>2H</i>)-diones Derivatives

Synthesis, Cyclooxygenases Inhibition Activities and Interactions with BSA of <i>N</i>-substituted 1<i>H</i>-pyrrolo[3,4-c]pyridine-1,3(<i>2H</i>)-diones Derivatives

Inhibition of cyclooxygenase is the way of therapeutic activities for anti-inflammatory pharmaceuticals. Serum albumins are the major soluble protein able to bind and transport a variety of exogenous and endogenous ligands, including hydrophobic pharmaceuticals. In this study, a novel <i>N<...

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Bibliographic Details
Main Authors: Edward Krzyżak, Dominika Szkatuła, Benita Wiatrak, Tomasz Gębarowski, Aleksandra Marciniak
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Molecules
Subjects:
pyrrolo-pyridine derivatives
cyclooxygenase
anti-inflammatory
serum albumin interactions
fluorescence quenching
molecular docking
Online Access:https://www.mdpi.com/1420-3049/25/12/2934

Internet

https://www.mdpi.com/1420-3049/25/12/2934

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