Effects of Combined CCR5/Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Naïve to Antiretroviral Therapy: A Pilot Randomized Trial.

Effects of Combined CCR5/Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Naïve to Antiretroviral Therapy: A Pilot Randomized Trial.

Whether initiation of antiretroviral therapy (ART) regimens aimed at achieving greater concentrations within gut associated lymphoid tissue (GALT) impacts the level of mucosal immune reconstitution, inflammatory markers and the viral reservoir remains unknown. We included 12 HIV- controls and 32 ART...

Full description

Bibliographic Details
Main Authors:	Sergio Serrano-Villar, Talia Sainz, Zhong-Min Ma, Netanya S Utay, Tae-Wook Chun, Surinder Mann, Angela D Kashuba, Basile Siewe, Anthony Albanese, Paolo Troia-Cancio, Elizabeth Sinclair, Anoma Somasunderam, Tammy Yotter, Steven G Deeks, Alan Landay, Richard B Pollard, Christopher J Miller, Santiago Moreno, David M Asmuth
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2016-01-01
Series:	PLoS Pathogens
Online Access:	https://doi.org/10.1371/journal.ppat.1005381

Similar Items

Correction: Effects of Combined CCR5/Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Naïve to Antiretroviral Therapy: A Pilot Randomized Trial.
by: Sergio Serrano-Villar, et al.
Published: (2016-03-01)

Correction: Effects of Combined CCR5/Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Naïve to Antiretroviral Therapy: A Pilot Randomized Trial.
by: Sergio Serrano-Villar, et al.
Published: (2017-05-01)

Adiponectin and the steatosis marker Chi3L1 decrease following switch to raltegravir compared to continued PI/NNRTI-based antiretroviral therapy.
by: Obiageli Offor, et al.
Published: (2018-01-01)

Serum Bovine Immunoglobulins Improve Inflammation and Gut Barrier Function in Persons with HIV and Enteropathy on Suppressive ART
by: Netanya Sandler Utay, et al.
Published: (2019-05-01)

Circulating LOXL2 Levels Reflect Severity of Intestinal Fibrosis and GALT CD4+ T Lymphocyte Depletion in Treated HIV Infection
by: Sophie Seang, et al.
Published: (2017-06-01)

HIV-2 integrase variation in integrase inhibitor-naïve adults in Senegal, West Africa.
by: Geoffrey S Gottlieb, et al.
Published: (2011-01-01)

Interferons and HIV Infection: The Good, the Bad, and the Ugly
by: Netanya Sandler Utay, et al.
Published: (2016-07-01)

Integrase and integration: biochemical activities of HIV-1 integrase
by: Deprez Eric, et al.
Published: (2008-12-01)

Neurological Response to cART vs. cART plus Integrase Inhibitor and CCR5 Antagonist Initiated during Acute HIV.
by: Victor G Valcour, et al.
Published: (2015-01-01)

Regulatory B cells inhibit cytotoxic T lymphocyte (CTL) activity and elimination of infected CD4 T cells after in vitro reactivation of HIV latent reservoirs.
by: Basile Siewe, et al.
Published: (2014-01-01)

Resistance to Integrase Inhibitors
by: Mathieu Métifiot, et al.
Published: (2010-06-01)

HIV integrase variability and genetic barrier in antiretroviral naïve and experienced patients
by: Comolli Giuditta, et al.
Published: (2011-03-01)

Relationship between HIV integrase polymorphisms and integrase inhibitor susceptibility: An in silico analysis
by: Hotma Martogi Lorensi Hutapea, et al.
Published: (2018-12-01)

The study of susceptibility and resistance of HIV integrases to integrase strand transfer inhibitors and the development of novel single domain antibody targeting HIV integrase
by: Ni, Xiaoju
Published: (2011)

The study of susceptibility and resistance of HIV integrases to integrase strand transfer inhibitors and the development of novel single domain antibody targeting HIV integrase
by: Ni, Xiaoju
Published: (2011)

The study of susceptibility and resistance of HIV integrases to integrase strand transfer inhibitors and the development of novel single domain antibody targeting HIV integrase
by: Ni, Xiaoju
Published: (2011)

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis
by: Jennifer L Elliott, et al.
Published: (2020-09-01)

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
by: Pratibha C Koneru, et al.
Published: (2019-05-01)

Evaluation of HIV-1 integrase resistance emergence and evolution in patients treated with integrase inhibitors
by: Rossana Scutari, et al.
Published: (2020-03-01)

MRSA Infections in HIV-Infected People Are Associated with Decreased MRSA-Specific Th1 Immunity.
by: Netanya S Utay, et al.
Published: (2016-04-01)

Molecular evolution of HIV-1 integrase during the 20 years prior to the first approval of integrase inhibitors
by: Karolin Meixenberger, et al.
Published: (2017-11-01)

A novel function for spumaretrovirus integrase: an early requirement for integrase-mediated cleavage of 2 LTR circles
by: Mouscadet Jean-François, et al.
Published: (2005-05-01)

GCN5-dependent acetylation of HIV-1 integrase enhances viral integration
by: Giacca Mauro, et al.
Published: (2009-09-01)

CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of Receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 Ligands
by: Jan Korbecki, et al.
Published: (2020-10-01)

GCN5-dependent acetylation of HIV-1 integrase enhances viral integration
by: Albanese Alberto, et al.
Published: (2010-03-01)

The mutational analysis of C31 integrase
by: Rowley, Paul Andrew
Published: (2007)

Study the functions of retroviral integrase in vivo
by: Peng, Wen Jiun, et al.
Published: (1995)

Mutations Located outside the Integrase Gene Can Confer Resistance to HIV-1 Integrase Strand Transfer Inhibitors
by: Isabelle Malet, et al.
Published: (2017-09-01)

Systematic Assessment of Chemokine Signaling at Chemokine Receptors CCR4, CCR7 and CCR10
by: Herman D. Lim, et al.
Published: (2021-04-01)

Antagonist of chemokine receptors CCR1 and CCR3
by: Ammit Alaina, et al.
Published: (2000-11-01)

Inhibition of HIV-1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal
by: Waigmann Elisabeth, et al.
Published: (2009-12-01)

Novel 3′-Processing Integrase Activity Assay by Real-Time PCR for Screening and Identification of HIV-1 Integrase Inhibitors
by: Supachai Sakkhachornphop, et al.
Published: (2015-01-01)

FcRL4 Expression Identifies a Pro-inflammatory B Cell Subset in Viremic HIV-Infected Subjects
by: Basile Siewe, et al.
Published: (2017-10-01)

HIV Integrase Inhibitor Pharmacogenetics: An Exploratory Study
by: Murrell, Derek E., et al.
Published: (2019)

Drug design targeted at HIV-1 Integrase
by: António José Meireles Ribeiro
Published: (2019)

The use of integrase inhibitors in treatment-experienced patients
by: Gatell Jose M
Published: (2009-11-01)

A New Freshwater Cyanosiphovirus Harboring Integrase
by: Kevin Xu Zhong, et al.
Published: (2018-09-01)

Structural basis for functional tetramerization of lentiviral integrase.
by: Stephen Hare, et al.
Published: (2009-07-01)

Biochemical characterization of novel retroviral integrase proteins.
by: Allison Ballandras-Colas, et al.
Published: (2013-01-01)

HIV-1 Integrase-DNA Recognition Mechanisms
by: Mamuka Kvaratskhelia, et al.
Published: (2009-11-01)

Cannot write session to /tmp/vufind_sessions/sess_hk39hl1e6us4jj7802qdn98oag