ShaPINg cell fate upon DNA damage:role of Pin1 isomerase in DNA damage-induced cell death and repair

ShaPINg cell fate upon DNA damage:role of Pin1 isomerase in DNA damage-induced cell death and repair

The peptidyl-prolyl cis/trans isomerase Pin1 acts as a molecular timer in proline-directed Ser/Thr kinase signaling and shapes cellular responses based on recognition of phosphorylation marks and implementing conformational changes in its substrates. Accordingly, Pin1 has been linked to numerous pho...

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Bibliographic Details
Main Authors: Thomas G Hofmann, Tilman ePollonio-Vallon
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Oncology
Subjects:
Apoptosis
DNA Repair
Telomere
Huntingtin
p73
Pin1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00148/full

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