High dose zinc supplementation induces hippocampal zinc deficiency and memory impairment with inhibition of BDNF signaling.

High dose zinc supplementation induces hippocampal zinc deficiency and memory impairment with inhibition of BDNF signaling.

Zinc ions highly concentrate in hippocampus and play a key role in modulating spatial learning and memory. At a time when dietary fortification and supplementation of zinc have increased the zinc consuming level especially in the youth, the toxicity of zinc overdose on brain function was underestima...

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Main Authors: Yang Yang, Xiao-Peng Jing, Shou-Peng Zhang, Run-Xia Gu, Fang-Xu Tang, Xiu-Lian Wang, Yan Xiong, Mei Qiu, Xu-Ying Sun, Dan Ke, Jian-Zhi Wang, Rong Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3561272?pdf=render

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