Blood–brain barrier disruption by stromelysin-1 facilitates neutrophil infiltration in neuroinflammation

Blood–brain barrier (BBB) opening is mediated by matrix metalloproteinases (MMPs) in neuroinflammation. We tested the hypothesis that MMP-3 plays a role in BBB damage, using MMP-3 knockout (KO) mice and lipopolysaccharide (LPS)-induced opening of the BBB. We found less disruption of the BBB after in...

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Bibliographic Details
Main Authors: Kate J. Gurney, Eduardo Y. Estrada, Gary A. Rosenberg
Format: Article
Language:English
Published: Elsevier 2006-07-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106000350

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