Janus kinase inhibitors suppress cancer cachexia‐associated anorexia and adipose wasting in mice

Janus kinase inhibitors suppress cancer cachexia‐associated anorexia and adipose wasting in mice

Abstract Background Cachexia, a syndrome of muscle atrophy, adipose loss, and anorexia, is associated with reduced survival in cancer patients. The colon adenocarcinoma C26c20 cell line secretes the cytokine leukaemia inhibitory factor (LIF), which induces cachexia. We characterized how LIF promotes...

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Bibliographic Details
Main Authors: Gurpreet K. Arora, Arun Gupta, Tong Guo, Aakash Y. Gandhi, Aaron Laine, Dorothy L. Williams, Chul Ahn, Puneeth Iyengar, Rodney E. Infante
Format: Article
Language:English
Published: Wiley 2020-07-01
Series:JCSM Rapid Communications
Subjects:
Cachexia
Cancer
Leukaemia inhibitory factor
IL‐6
Leptin
Janus kinase
Online Access:https://doi.org/10.1002/rco2.24

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