MiR-34a suppression targets Nampt to ameliorate bone marrow mesenchymal stem cell senescence by regulating NAD+-Sirt1 pathway

MiR-34a suppression targets Nampt to ameliorate bone marrow mesenchymal stem cell senescence by regulating NAD+-Sirt1 pathway

Abstract Background Expansion-mediated replicative senescence and age-related natural senescence have adverse effects on mesenchymal stem cell (MSC) regenerative capability and functionality, thus severely impairing the extensive applications of MSC-based therapies. Emerging evidences suggest that m...

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Bibliographic Details
Main Authors: Chenchen Pi, Cao Ma, Huan Wang, Hui Sun, Xiao Yu, Xingyu Gao, Yue Yang, Yanan Sun, Haiying Zhang, Yingai Shi, Yan Li, Yulin Li, Xu He
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cell
Senescence
miRNA
miR-34a
Nampt
Regulation
Online Access:https://doi.org/10.1186/s13287-021-02339-0

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