Targeting DNA Damage Repair for Immune Checkpoint Inhibition: Mechanisms and Potential Clinical Applications

Targeting DNA Damage Repair for Immune Checkpoint Inhibition: Mechanisms and Potential Clinical Applications

DNA damage repair (DDR) pathways play an essential role in maintaining genomic integrity. DDR dysfunction leads to accumulated DNA damage, predisposition to cancer, and high sensitivity to chemotherapy and radiotherapy. Recent studies have demonstrated that DDR status is associated with response to...

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Bibliographic Details
Main Authors: Wei Sun, Qing Zhang, Runkun Wang, Yang Li, Yue Sun, Lin Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
immune checkpoint inhibitors
predictive biomarker for prognosis
target therapy
DNA damage repair
combined therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.648687/full

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