Slowing of the Time Course of Acidification Decreases the Acid-Sensing Ion Channel 1a Current Amplitude and Modulates Action Potential Firing in Neurons

Slowing of the Time Course of Acidification Decreases the Acid-Sensing Ion Channel 1a Current Amplitude and Modulates Action Potential Firing in Neurons

Acid-sensing ion channels (ASICs) are H+-activated neuronal Na+ channels. They are involved in fear behavior, learning, neurodegeneration after ischemic stroke and in pain sensation. ASIC activation has so far been studied only with fast pH changes, although the pH changes associated with many roles...

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Bibliographic Details
Main Authors: Omar Alijevic, Olivier Bignucolo, Echrak Hichri, Zhong Peng, Jan P. Kucera, Stephan Kellenberger
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
acidification
ASIC
kinetic model
Hodgkin-Huxley model
neuronal signaling
patch-clamp
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00041/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2020.00041/full

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