Cluster Analysis of p53 Binding Site Sequences Reveals Subsets with Different Functions

Cluster Analysis of p53 Binding Site Sequences Reveals Subsets with Different Functions

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p53 is an important regulator of cell cycle arrest, senescence, apoptosis and metabolism, and is frequently mutated in tumors. It functions as a tetramer, where each component dimer binds to a decameric DNA region known as a response element. We identify p53 binding site subtypes and examine the fun...

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Bibliographic Details
Main Authors:	Ji-Hyun Lim, Natasha S. Latysheva, Richard D. Iggo, Daniel Barker
Format:	Article
Language:	English
Published:	SAGE Publishing 2016-01-01
Series:	Cancer Informatics
Online Access:	https://doi.org/10.4137/CIN.S39968

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