14-Thienyl Methylene Matrine (YYJ18), the Derivative from Matrine, Induces Apoptosis of Human Nasopharyngeal Carcinoma Cells by Targeting MAPK and PI3K/Akt Pathways in Vitro

14-Thienyl Methylene Matrine (YYJ18), the Derivative from Matrine, Induces Apoptosis of Human Nasopharyngeal Carcinoma Cells by Targeting MAPK and PI3K/Akt Pathways in Vitro

Background/Aims: Nasopharyngeal carcinoma (NPC) is a distinctive type of head and neck cancer with the highest incidence in South China. Previous studies have proved that matrine, a main alkaloid isolated from Sophora flavescens Ait, has antitumor activity against NPC. However, the effect is not so...

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Bibliographic Details
Main Authors: Mao Xie, Xiang Yi, Renjun Wang, Lisheng Wang, Guangyao He, Meichan Zhu, Chenglin Qi, Yikang Liu, Yu Ye, Songhua Tan, Anzhou Tang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
14-thienyl methylene matrine
Akt
Nasopharyngeal carcinoma
Apoptosis
MAPK
Online Access:http://www.karger.com/Article/FullText/358712

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