Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling

Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling

Abstract Background CXCL12(chemokine ligand 12, CXCL12) and its receptors CXCR4 are widely expressed in maternal-fetal interface and plays an adjust role in materno-fetal dialogue and immune tolerance during early pregnancy. This study aimed to evaluate the role and mechanism of self-derived CXCL12...

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Bibliographic Details
Main Authors: Jiayi Zheng, Danni Qu, Chen Wang, Ling Ding, Wenhui Zhou
Format: Article
Language:English
Published: BMC 2020-02-01
Series:BMC Pregnancy and Childbirth
Subjects:
Endometrial epithelial cell (EEC)
Motility
CXCL12/CXCR4
Phosphorylation
Maternal-fetal interface
Online Access:https://doi.org/10.1186/s12884-020-2788-3

Internet

https://doi.org/10.1186/s12884-020-2788-3

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