Hypoxia Induces autophagic cell death through hypoxia-inducible factor 1α in microglia.

As phagocytic cells of central nervous system, excessive activation or cell death of microglia is involved in a lot of nervous system injury and degenerative disease, such as stroke, epilepsy, Parkinson's disease, Alzheimer's disease. Accumulating evidence indicates that hypoxia upregulate...

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Bibliographic Details
Main Authors: Zhao Yang, Tian-Zhi Zhao, Yong-Jie Zou, John H Zhang, Hua Feng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4018331?pdf=render