Blocking mTOR Signalling with Rapamycin Ameliorates Imiquimod-induced Psoriasis in Mice

Blocking mTOR Signalling with Rapamycin Ameliorates Imiquimod-induced Psoriasis in Mice

The mTOR (mechanistic target of rapamycin) inhibitor rapamycin has long been known for its immune suppressive properties, but it has shown limited therapeutic success when given systemically to patients with psoriasis. Recent data have shown that the mTOR pathway is hyperactivated in lesional psoria...

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Bibliographic Details
Main Authors:	Claudia Bürger, Nitesh Shirsath, Victoria Lang, Sandra Diehl, Roland Kaufmann, Andreas Weigert, Ying-ying Han, Christian Ringel, Peter Wolf
Format:	Article
Language:	English
Published:	Society for Publication of Acta Dermato-Venereologica 2017-06-01
Series:	Acta Dermato-Venereologica
Subjects:	psoriasis imiquimod rapamycin mTORC
Online Access:	https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2724

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