Matched Whole-Genome Sequencing (WGS) and Whole-Exome Sequencing (WES) of Tumor Tissue with Circulating Tumor DNA (ctDNA) Analysis: Complementary Modalities in Clinical Practice

Matched Whole-Genome Sequencing (WGS) and Whole-Exome Sequencing (WES) of Tumor Tissue with Circulating Tumor DNA (ctDNA) Analysis: Complementary Modalities in Clinical Practice

Tumor heterogeneity, especially intratumoral heterogeneity, is a primary reason for treatment failure. A single biopsy may not reflect the complete genomic architecture of the tumor needed to make therapeutic decisions. Circulating tumor DNA (ctDNA) is believed to overcome these limitations. We anal...

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Bibliographic Details
Main Authors: Robin Imperial, Marjan Nazer, Zaheer Ahmed, Audrey E. Kam, Timothy J. Pluard, Waled Bahaj, Mia Levy, Timothy M. Kuzel, Dana M. Hayden, Sam G. Pappas, Janakiraman Subramanian, Ashiq Masood
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
circulating tumor DNA
next generation sequencing
driver alterations
actionable alterations
concordance
Online Access:https://www.mdpi.com/2072-6694/11/9/1399

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https://www.mdpi.com/2072-6694/11/9/1399

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