Detection of Lysyl Oxidase Activity in Tumor Extracellular Matrix Using Peptide-Functionalized Gold Nanoprobes

Detection of Lysyl Oxidase Activity in Tumor Extracellular Matrix Using Peptide-Functionalized Gold Nanoprobes

High LOX levels in the tumor microenvironment causes the cross-linking of extracellular matrix components and increases the stiffness of tumor tissue. Thus, LOX plays an important role in tumorigenesis and in lowering the tumor response to anticancer drugs. Despite comprehensive efforts to identify...

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Bibliographic Details
Main Authors: Han Young Kim, Mihee Jo, Ju A La, Youngjin Choi, Eun Chul Cho, Su Hee Kim, Youngmee Jung, Kwangmeyung Kim, Ju Hee Ryu
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
lysyl oxidase
gold nanoparticles
colorimetric assays
extracellular matrix
tumor stiffness
Online Access:https://www.mdpi.com/2072-6694/13/18/4523

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