Cdk7 Is Required for Activity-Dependent Neuronal Gene Expression, Long-Lasting Synaptic Plasticity and Long-Term Memory

Cdk7 Is Required for Activity-Dependent Neuronal Gene Expression, Long-Lasting Synaptic Plasticity and Long-Term Memory

In the brain, de novo gene expression driven by learning-associated neuronal activities is critical for the formation of long-term memories. However, the signaling machinery mediating neuronal activity-induced gene expression, especially the rapid transcription of immediate-early genes (IEGs) remain...

Full description

Bibliographic Details
Main Authors: Guiqin He, Xiangyu Yang, Guo Wang, Junxia Qi, Rui Mao, Zhengping Wu, Zikai Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Cdk7
immediate early gene
synpatic plasticity
long-term memory
THZ1
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00365/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00365/full

Similar Items