Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms.

Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms.

Toll-like receptors (TLRs) are innate immune receptors that sense a variety of pathogen-associated molecular patterns (PAMPs) by interacting with them and subsequently initiating signal transduction cascades that elicit immune responses. TLR11 has been shown to interact with two known protein PAMPs:...

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Main Authors: Hirotsugu Hatai, Alice Lepelley, Wangyong Zeng, Matthew S Hayden, Sankar Ghosh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4747465?pdf=render
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spelling doaj-4bfbb5f151354d81a7c2d424e245eca82020-11-25T02:55:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01112e014898710.1371/journal.pone.0148987Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms.Hirotsugu HataiAlice LepelleyWangyong ZengMatthew S HaydenSankar GhoshToll-like receptors (TLRs) are innate immune receptors that sense a variety of pathogen-associated molecular patterns (PAMPs) by interacting with them and subsequently initiating signal transduction cascades that elicit immune responses. TLR11 has been shown to interact with two known protein PAMPs: Salmonella and E. coli flagellin FliC and Toxoplasma gondii profilin-like protein. Given the highly divergent biology of these pathogens recognized by TLR11, it is unclear whether common mechanisms are used to recognize these distinct protein PAMPs. Here we show that TLR11 interacts with these two PAMPs using different receptor domains. Furthermore, TLR11 binding to flagellin and profilin exhibits differential dependency on pH and receptor ectodomain cleavage.http://europepmc.org/articles/PMC4747465?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Hirotsugu Hatai
Alice Lepelley
Wangyong Zeng
Matthew S Hayden
Sankar Ghosh
spellingShingle Hirotsugu Hatai
Alice Lepelley
Wangyong Zeng
Matthew S Hayden
Sankar Ghosh
Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms.
PLoS ONE
author_facet Hirotsugu Hatai
Alice Lepelley
Wangyong Zeng
Matthew S Hayden
Sankar Ghosh
author_sort Hirotsugu Hatai
title Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms.
title_short Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms.
title_full Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms.
title_fullStr Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms.
title_full_unstemmed Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms.
title_sort toll-like receptor 11 (tlr11) interacts with flagellin and profilin through disparate mechanisms.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2016-01-01
description Toll-like receptors (TLRs) are innate immune receptors that sense a variety of pathogen-associated molecular patterns (PAMPs) by interacting with them and subsequently initiating signal transduction cascades that elicit immune responses. TLR11 has been shown to interact with two known protein PAMPs: Salmonella and E. coli flagellin FliC and Toxoplasma gondii profilin-like protein. Given the highly divergent biology of these pathogens recognized by TLR11, it is unclear whether common mechanisms are used to recognize these distinct protein PAMPs. Here we show that TLR11 interacts with these two PAMPs using different receptor domains. Furthermore, TLR11 binding to flagellin and profilin exhibits differential dependency on pH and receptor ectodomain cleavage.
url http://europepmc.org/articles/PMC4747465?pdf=render
work_keys_str_mv AT hirotsuguhatai tolllikereceptor11tlr11interactswithflagellinandprofilinthroughdisparatemechanisms
AT alicelepelley tolllikereceptor11tlr11interactswithflagellinandprofilinthroughdisparatemechanisms
AT wangyongzeng tolllikereceptor11tlr11interactswithflagellinandprofilinthroughdisparatemechanisms
AT matthewshayden tolllikereceptor11tlr11interactswithflagellinandprofilinthroughdisparatemechanisms
AT sankarghosh tolllikereceptor11tlr11interactswithflagellinandprofilinthroughdisparatemechanisms
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