Brain Metastasis from Gastrointestinal Stromal Tumor: A Case Report and Review of the Literature

• Main Authors: Hideaki Naoe, Eisuke Kaku, Yumi Ido, Rika Gushima, Yoko Maki, Hirokazu Saito, Seiichiro Yokote, Ryosuke Gushima, Kouichi Nonaka, Yohmei Hoshida, Tetsuya Murao, Tetsu Ozaki, Kazunori Yokomine, Hideki Tanaka, Hiroyasu Nagahama, Kouichi Sakurai, Motohiko Tanaka, Ken-ichi Iyama, Hideo Baba, Yutaka Sasaki
• Format: Article
• Language: English
• Published: Karger Publishers 2011-10-01
• Series: Case Reports in Gastroenterology
• Subjects: Mutational analysis; Gastrointestinal stromal tumor; Brain metastasis
• Online Access: http://www.karger.com/Article/FullText/333403

Metastasis of gastrointestinal stromal tumor (GIST) into the central nervous system is extremely rare. We report a patient with synchronous GIST and brain metastasis. At disease onset, there was left hemiplegia and ptosis of the right eyelids. Resection cytology of the brain tumor was reported as metastasis of GIST. After positron emission tomography examination, another tumor in the small bowel was discovered, which suggested a small bowel GIST associated with intracranial metastasis. Immunohistochemical analysis of the intestinal tumor specimen obtained by double balloon endoscopy showed a pattern similar to the brain tumor, with the tumors subsequently identified as intracranial metastases of jejunal GIST. After surgical resection of one brain tumor, the patient underwent whole brain radiation therapy followed by treatment with imatinib mesylate (Gleevec; Novartis Pharma, Basel, Switzerland). Mutational analysis of the original intestinal tumor revealed there were no gene alterations in KIT or PDGFRα. Since the results indicated the treatment had no apparent effect on either of the tumors, and because ileus developed due to an intestinal primary tumor, the patient underwent surgical resection of the intestinal lesion. However, the patient’s condition gradually worsen and she subsequently died 4 months after the initial treatment.