Attenuation of Nrf2/Keap1/ARE in Alzheimer’s Disease by Plant Secondary Metabolites: A Mechanistic Review

Attenuation of Nrf2/Keap1/ARE in Alzheimer’s Disease by Plant Secondary Metabolites: A Mechanistic Review

Alzheimer’s disease (AD) is a progressive neuronal/cognitional dysfunction, leading to disability and death. Despite advances in revealing the pathophysiological mechanisms behind AD, no effective treatment has yet been provided. It urges the need for finding novel multi-target agents in combating t...

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Bibliographic Details
Main Authors: Sajad Fakhri, Mirko Pesce, Antonia Patruno, Seyed Zachariah Moradi, Amin Iranpanah, Mohammad Hosein Farzaei, Eduardo Sobarzo-Sánchez
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
Alzheimer’s disease
oxidative stress
Nrf2
Keap1
antioxidant response elements
phytochemicals
Online Access:https://www.mdpi.com/1420-3049/25/21/4926

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