Performance comparison between the mycobacteria growth indicator tube system and Löwenstein-Jensen medium in the routine detection of Mycobacterium tuberculosis at public health care facilities in Rio de Janeiro, Brazil: preliminary results of a pragmatic clinical trial

• Main Authors: Adriana da Silva Rezende Moreira, Gisele Huf, Maria Armanda Vieira, Leila Fonseca, Monica Ricks, Afranio Lineu Kritski
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Pneumologia e Tisiologia 2013-06-01
• Series: Jornal Brasileiro de Pneumologia
• Subjects: Ensaio clinico controlado; Tuberculose; Testes diagnosticos de rotina
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132013000300365&lng=en&tlng=en

In view of the fact that the World Health Organization has recommended the use of the mycobacteria growth indicator tube (MGIT) 960 system for the diagnosis of tuberculosis and that there is as yet no evidence regarding the clinical impact of its use in health care systems, we conducted a pragmatic clinical trial to evaluate the clinical performance and cost-effectiveness of the use of MGIT 960 at two health care facilities in the city of Rio de Janeiro, Brazil, where the incidence of tuberculosis is high. Here, we summarize the methodology and preliminary results of the trial. (ISRCTN.org Identifier: ISRCTN79888843 [http://isrctn.org/])