Antidiabetic and antihyperlipidemic effect of Duvalia corderoyi in rats with streptozotocin-induced diabetes

• Main Authors: Nora A. AlFaris, Ghedeir M. Alshammari, Muneer M. Alsayadi, Munirah A. AlFaris, Mohammed A. Yahya
• Format: Article
• Language: English
• Published: Elsevier 2020-03-01
• Series: Saudi Journal of Biological Sciences
• Online Access: http://www.sciencedirect.com/science/article/pii/S1319562X20300255

Diabetes mellitus (DM) is a metabolic syndrome distinguished with glucose increasing in blood, insulin resistance, and hyperlipidemia. It results in decease of millions of people yearly. Duvalia corderoyi is a traditional diabetes and hypertension medicine from the Arabian region. D. corderoyi extract was administered to diabetes rats for estimate its anti-diabetic and antihyperlipidemic activities in Wistar rats were induced using (60 mg/kg) of streptozotocin (STZ) intraperitoneally. The rats were randomly divided into five groups: control, diabetic, diabetic receiving glibenclamide, and two diabetic D. corderoyi-treatment groups. Rats were weighted weekly, and the biochemical analysis were carried out in serum, and liver homogenate samples. Body weight of diabetic rats was lessening significantly D. corderoyi improved body weight, glucose concentration, lipid profiles, hepatic enzymes, urea, creatinine, insulin, and HDL-C. These results are the first to indicate the potential antidiabetic and antihyperlipidemic activities of D. corderoyi. Keywords: Antidiabetic, Antihyperlipidemic, Duvalia corderoyi