A role for taurine in mitochondrial function

A role for taurine in mitochondrial function

<p>Abstract</p> <p>The mitochondrial pH gradient across the inner-membrane is stabilised by buffering of the matrix. A low-molecular mass buffer compound has to be localised in the matrix to maintain its alkaline pH value. Taurine is found ubiquitously in animal cells with concentr...

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Main Authors: Hansen Svend, Andersen Mogens, Cornett Claus, Gradinaru Robert, Grunnet Niels
Format: Article
Language:English
Published: BMC 2010-08-01
Series:Journal of Biomedical Science
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spelling doaj-4befd29fa59b4cedbf6c39074e17e2012020-11-25T02:56:37ZengBMCJournal of Biomedical Science1021-77701423-01272010-08-0117Suppl 1S2310.1186/1423-0127-17-S1-S23A role for taurine in mitochondrial functionHansen SvendAndersen MogensCornett ClausGradinaru RobertGrunnet Niels<p>Abstract</p> <p>The mitochondrial pH gradient across the inner-membrane is stabilised by buffering of the matrix. A low-molecular mass buffer compound has to be localised in the matrix to maintain its alkaline pH value. Taurine is found ubiquitously in animal cells with concentrations in the millimolar range and its pKa value is determined to 9.0 (25°C) and 8.6 (37°C), respectively. Localisation of such a low-molecular buffer in the mitochondrial matrix, transforms the matrix into a biochemical reaction chamber for the important matrix-localised enzyme systems. Three acyl-CoA dehydrogenase enzymes, which are pivotal for beta-oxidation of fatty acids, are demonstrated to have optimal activity in a taurine buffer. By application of the model presented, taurine depletion caused by hyperglycemia could provide a link between mitochondrial dysfunction and diabetes.</p>
collection DOAJ
language English
format Article
sources DOAJ
author Hansen Svend
Andersen Mogens
Cornett Claus
Gradinaru Robert
Grunnet Niels
spellingShingle Hansen Svend
Andersen Mogens
Cornett Claus
Gradinaru Robert
Grunnet Niels
A role for taurine in mitochondrial function
Journal of Biomedical Science
author_facet Hansen Svend
Andersen Mogens
Cornett Claus
Gradinaru Robert
Grunnet Niels
author_sort Hansen Svend
title A role for taurine in mitochondrial function
title_short A role for taurine in mitochondrial function
title_full A role for taurine in mitochondrial function
title_fullStr A role for taurine in mitochondrial function
title_full_unstemmed A role for taurine in mitochondrial function
title_sort role for taurine in mitochondrial function
publisher BMC
series Journal of Biomedical Science
issn 1021-7770
1423-0127
publishDate 2010-08-01
description <p>Abstract</p> <p>The mitochondrial pH gradient across the inner-membrane is stabilised by buffering of the matrix. A low-molecular mass buffer compound has to be localised in the matrix to maintain its alkaline pH value. Taurine is found ubiquitously in animal cells with concentrations in the millimolar range and its pKa value is determined to 9.0 (25°C) and 8.6 (37°C), respectively. Localisation of such a low-molecular buffer in the mitochondrial matrix, transforms the matrix into a biochemical reaction chamber for the important matrix-localised enzyme systems. Three acyl-CoA dehydrogenase enzymes, which are pivotal for beta-oxidation of fatty acids, are demonstrated to have optimal activity in a taurine buffer. By application of the model presented, taurine depletion caused by hyperglycemia could provide a link between mitochondrial dysfunction and diabetes.</p>
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