Normal platelet mitochondrial complex I activity in Huntington’s Disease

Normal platelet mitochondrial complex I activity in Huntington’s Disease

Two small case series of platelet mitochondrial complex I activity assays in Huntington’s Disease (HD) report discrepant results. We measured platelet complex I and complex I/III activity in 21 subjects with early gene-positive HD and 14 age-matched controls. The 21 participants with HD that we stud...

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Bibliographic Details
Main Authors: William J. Powers, Richard H. Haas, Thuy Le, Tom O. Videen, Tamara Hershey, Lori McGee-Minnich, Joel S. Perlmutter
Format: Article
Language:English
Published: Elsevier 2007-07-01
Series:Neurobiology of Disease
Subjects:
Huntington’s Disease
Mitochondria
Electron transport system
Platelets
Human
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107000915
Description
Summary:Two small case series of platelet mitochondrial complex I activity assays in Huntington’s Disease (HD) report discrepant results. We measured platelet complex I and complex I/III activity in 21 subjects with early gene-positive HD and 14 age-matched controls. The 21 participants with HD that we studied are greater than the total of 16 in the two previously published of platelet ETS activity in HD. Reductions ?>>10% were excluded with 80% confidence. A systemic defect in complex I activity is not present in early HD when striatal neuronal degeneration is already present.
ISSN:1095-953X

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