Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Disease through Hdac3 Participation in Mice

Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Disease through Hdac3 Participation in Mice

Background: Valproic acid (VPA) exposure during pregnancy has been proven to contribute to congenital heart disease (CHD). Our previous findings implied that disruption of planar cell polarity (PCP) signaling pathway in cardiomyocytes might be a factor for the cardiac teratogenesis of VPA. In additi...

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Bibliographic Details
Main Authors: Hong-Yu Duan, Kai-Yu Zhou, Tao Wang, Yi Zhang, Yi-Fei Li, Yi-Min Hua, Chuan Wang
Format: Article
Language:English
Published: Wolters Kluwer 2018-01-01
Series:Chinese Medical Journal
Subjects:
Congenital Heart Disease; Hdacs; Planar Cell Polarity; Valproic Acid
Online Access:http://www.cmj.org/article.asp?issn=0366-6999;year=2018;volume=131;issue=17;spage=2080;epage=2088;aulast=Duan

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