Increased Sirt1 secreted from visceral white adipose tissue is associated with improved glucose tolerance in obese Nrf2-deficient mice

Increased Sirt1 secreted from visceral white adipose tissue is associated with improved glucose tolerance in obese Nrf2-deficient mice

Obesity is associated with metabolic dysregulation characterized by insulin resistance and glucose intolerance. Nuclear factor E2-related factor (Nrf2) is a critical regulator of the stress response and Nrf2-deficient mice (Nrf2−/−) are protected against high fat diet (HFD)-induced metabolic derange...

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Bibliographic Details
Main Authors: Laura Braud, Maria Pini, Donald F. Stec, Sylvie Manin, Geneviève Derumeaux, David E. Stec, Roberta Foresti, Roberto Motterlini
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Redox Biology
Subjects:
Nrf2
Sirtuin 1
Obesity
White adipose tissue
Glucose metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720310107

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http://www.sciencedirect.com/science/article/pii/S2213231720310107

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