Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection
Cytokines and their associated pathways can affect survival ofMycobacterium tuberculosis in macrophages, representing potential targets for host-directed therapies. Here, Péan et al. show that cytokine-STAT signalling promotes mycobacterial survival within macrophages by deregulating lipid droplet h...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2017-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms14642 |
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doaj-4bd8daccf57b461585b4d2bad37cf1c12021-05-11T07:02:55ZengNature Publishing GroupNature Communications2041-17232017-03-018111110.1038/ncomms14642Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infectionClaire B. Péan0Mark Schiebler1Sharon W. S. Tan2Jessica A. Sharrock3Katrin Kierdorf4Karen P. Brown5M. Charlotte Maserumule6Shinelle Menezes7Martina Pilátová8Kévin Bronda9Pierre Guermonprez10Brian M. Stramer11R. Andres Floto12Marc S. Dionne13and Department of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, Imperial College LondonUniversity of Cambridge Department of Medicine, Molecular Immunity Unit, MRC Laboratory of Molecular BiologyCentre for Molecular and Cellular Biology of Inflammation, School of Medicine, King’s College Londonand Department of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, Imperial College Londonand Department of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, Imperial College LondonUniversity of Cambridge Department of Medicine, Molecular Immunity Unit, MRC Laboratory of Molecular BiologyUniversity of Cambridge Department of Medicine, Molecular Immunity Unit, MRC Laboratory of Molecular BiologyCentre for Molecular and Cellular Biology of Inflammation, School of Medicine, King’s College LondonRandall Division of Cell and Molecular Biophysics, King’s College LondonCentre for Molecular and Cellular Biology of Inflammation, School of Medicine, King’s College LondonCentre for Molecular and Cellular Biology of Inflammation, School of Medicine, King’s College LondonRandall Division of Cell and Molecular Biophysics, King’s College LondonUniversity of Cambridge Department of Medicine, Molecular Immunity Unit, MRC Laboratory of Molecular Biologyand Department of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, Imperial College LondonCytokines and their associated pathways can affect survival ofMycobacterium tuberculosis in macrophages, representing potential targets for host-directed therapies. Here, Péan et al. show that cytokine-STAT signalling promotes mycobacterial survival within macrophages by deregulating lipid droplet homeostasis.https://doi.org/10.1038/ncomms14642 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Claire B. Péan Mark Schiebler Sharon W. S. Tan Jessica A. Sharrock Katrin Kierdorf Karen P. Brown M. Charlotte Maserumule Shinelle Menezes Martina Pilátová Kévin Bronda Pierre Guermonprez Brian M. Stramer R. Andres Floto Marc S. Dionne |
| spellingShingle |
Claire B. Péan Mark Schiebler Sharon W. S. Tan Jessica A. Sharrock Katrin Kierdorf Karen P. Brown M. Charlotte Maserumule Shinelle Menezes Martina Pilátová Kévin Bronda Pierre Guermonprez Brian M. Stramer R. Andres Floto Marc S. Dionne Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection Nature Communications |
| author_facet |
Claire B. Péan Mark Schiebler Sharon W. S. Tan Jessica A. Sharrock Katrin Kierdorf Karen P. Brown M. Charlotte Maserumule Shinelle Menezes Martina Pilátová Kévin Bronda Pierre Guermonprez Brian M. Stramer R. Andres Floto Marc S. Dionne |
| author_sort |
Claire B. Péan |
| title |
Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection |
| title_short |
Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection |
| title_full |
Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection |
| title_fullStr |
Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection |
| title_full_unstemmed |
Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection |
| title_sort |
regulation of phagocyte triglyceride by a stat-atg2 pathway controls mycobacterial infection |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-03-01 |
| description |
Cytokines and their associated pathways can affect survival ofMycobacterium tuberculosis in macrophages, representing potential targets for host-directed therapies. Here, Péan et al. show that cytokine-STAT signalling promotes mycobacterial survival within macrophages by deregulating lipid droplet homeostasis. |
| url |
https://doi.org/10.1038/ncomms14642 |
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