N1-Methylnicotinamide Improves Hepatic Insulin Sensitivity via Activation of SIRT1 and Inhibition of FOXO1 Acetylation

N1-Methylnicotinamide Improves Hepatic Insulin Sensitivity via Activation of SIRT1 and Inhibition of FOXO1 Acetylation

Objective. To explore the effects of N1-methylnicotinamide (MNAM) on insulin resistance and glucose metabolism in obese type 2 diabetes mellitus (T2DM) mice and regulatory mechanisms of the NAD-dependent deacetylase sirtuin-1 (SIRT1)/forkhead box protein O1 (FOXO1) pathway. Methods. Blood glucose an...

Full description

Bibliographic Details
Main Authors:	Jingfan Zhang, Yu Chen, Cong Liu, Ling Li, Ping Li
Format:	Article
Language:	English
Published:	Hindawi Limited 2020-01-01
Series:	Journal of Diabetes Research
Online Access:	http://dx.doi.org/10.1155/2020/1080152

Similar Items

EP300 and SIRT1/6 Co-Regulate Lapatinib Sensitivity Via Modulating FOXO3-Acetylation and Activity in Breast Cancer
by: Zimam Mahmud, et al.
Published: (2019-07-01)

SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL
by: Partha Chakrabarti, et al.
Published: (2011-09-01)

Exendin-4 Upregulates Adiponectin Level in Adipocytes via Sirt1/Foxo-1 Signaling Pathway.
by: Anping Wang, et al.
Published: (2017-01-01)

Insulin/IGF-1R, SIRT1, and FOXOs Pathways—An Intriguing Interaction Platform for Bone and Osteosarcoma
by: Consolato Sergi, et al.
Published: (2019-03-01)

Salidroside Inhibits HMGB1 Acetylation and Release through Upregulation of SirT1 during Inflammation
by: Zhilin Qi, et al.
Published: (2017-01-01)

Modulation of SIRT1-Foxo1 Signaling axis by Resveratrol: Implications in Skeletal Muscle Aging and Insulin Resistance
by: Thomas K. Sin, et al.
Published: (2015-01-01)

Effects of 1-Methylnicotinamide (MNA) on Exercise Capacity and Endothelial Response in Diabetic Mice.
by: Kamil Przyborowski, et al.
Published: (2015-01-01)

Resveratrol Promotes Diabetic Wound Healing via SIRT1-FOXO1-c-Myc Signaling Pathway-Mediated Angiogenesis
by: Xiaozhong Huang, et al.
Published: (2019-04-01)

MiRNA 34-a regulate SIRT-1 and Foxo-1 expression in endometriosis
by: Noha A. Rezk, et al.
Published: (2021-03-01)

Targeting the core of neurodegeneration: FoxO, mTOR, and SIRT1
by: Kenneth Maiese
Published: (2021-01-01)

Nanomechanical sensing of the endothelial cell response to anti-inflammatory action of 1-methylnicotinamide chloride
by: Kolodziejczyk AM, et al.
Published: (2013-08-01)

SIRT1-FOXO3a Regulate Cocaine Actions in the Nucleus Accumbens
by: Ferguson, Deveroux, et al.
Published: (2015)

Substrate-Dependent Sensitivity of SIRT1 to Nicotinamide Inhibition
by: Stacia Rymarchyk, et al.
Published: (2021-02-01)

The role of SIRT6 and FOXO3a acetylation in the development of drug resistance in breast cancer
by: Khongkow, Mattaka
Published: (2014)

Safety of 1‐methylnicotinamide chloride (1‐MNA) as a novel food pursuant to Regulation (EC) No 258/97
by: EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), et al.
Published: (2017-10-01)

SIRT3 promotion reduces resistance to cisplatin in lung cancer by modulating the FOXO3/CDT1 axis
by: Yang Cao, et al.
Published: (2021-02-01)

Ginkgolide B Protects Cardiomyocytes from Angiotensin II-Induced Hypertrophy via Regulation of Autophagy through SIRT1-FoxO1
by: Qingyuan Jiang, et al.
Published: (2021-01-01)

N-methylnicotinamide as marker for biological methylation in humans
by: Rosemann, G.M. (Gertruida Magdalena)
Published: (2013)

Inhibition of FOXO1 by small interfering RNA enhances proliferation and inhibits apoptosis of papillary thyroid carcinoma cells via Akt/FOXO1/Bim pathway
by: Song HM, et al.
Published: (2015-12-01)

Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress.
by: Yusuke S Hori, et al.
Published: (2013-01-01)

FOXO3a Protects against Kidney Injury in Type II Diabetic Nephropathy by Promoting Sirt6 Expression and Inhibiting Smad3 Acetylation
by: Xiaowei Wang, et al.
Published: (2021-01-01)

Protective Effects of N1-Methylnicotinamide Against High-Fat Diet- and Age-Induced Hearing Loss via Moderate Overexpression of Sirtuin 1 Protein
by: Toru Miwa, et al.
Published: (2021-04-01)

SIRT1 and FOXO1 mRNA expression in PBMC correlates to physical activity in COPD patients
by: Taka C, et al.
Published: (2017-11-01)

Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal
by: Shasha Song, et al.
Published: (2019-09-01)

The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO.
by: Gizem Rizki, et al.
Published: (2011-09-01)

Role of acetylation in nonalcoholic fatty liver disease: a focus on SIRT1 and SIRT3
by: Fatiha Nassir
Published: (2020-08-01)

Inhibition studies of SIRT1
by: Bonetti, Kelly
Published: (2015)

PXDN reduces autophagic flux in insulin-resistant cardiomyocytes via modulating FoxO1
by: Chan Li, et al.
Published: (2021-04-01)

SIRT1 and FOXO Mediate Contractile Differentiation of Vascular Smooth Muscle Cells under Cyclic Stretch
by: Kai Huang, et al.
Published: (2015-11-01)

Cx43 Inhibition Attenuates Sepsis-Induced Intestinal Injury via Downregulating ROS Transfer and the Activation of the JNK1/Sirt1/FoxO3a Signaling Pathway
by: Zhaowei Zou, et al.
Published: (2019-01-01)

Ets1-Mediated Acetylation of FoxO1 Is Critical for Gluconeogenesis Regulation during Feed-Fast Cycles
by: Kai Li, et al.
Published: (2019-03-01)

Resveratrol Ameliorates Contrast Induced Nephropathy Through the Activation of SIRT1-PGC-1α-Foxo1 Signaling in Mice
by: Yu Ah Hong, et al.
Published: (2017-10-01)

Adipose Tissue SIRT1 Regulates Insulin Sensitizing and Anti-Inflammatory Effects of Berberine
by: Yun Shan, et al.
Published: (2020-12-01)

LncRNA H19 promotes the differentiation of bovine skeletal muscle satellite cells by suppressing Sirt1/FoxO1
by: Xiaochun Xu, et al.
Published: (2017-06-01)

Hepatic FoxO1 acetylation is involved in oleanolic acid-induced memory of glycemic control: novel findings from Study 2.
by: Xiu Zhou, et al.
Published: (2014-01-01)

Salidroside protects against ox-LDL-induced endothelial injury by enhancing autophagy mediated by SIRT1-FoxO1 pathway
by: Zhongsheng Zhu, et al.
Published: (2019-05-01)

Nobiletin ameliorates hepatic ischemia and reperfusion injury through the activation of SIRT-1/FOXO3a-mediated autophagy and mitochondrial biogenesis
by: Theodomir Dusabimana, et al.
Published: (2019-04-01)

Hypertrophy of Rat Skeletal Muscle Is Associated with Increased SIRT1/Akt/mTOR/S6 and Suppressed Sestrin2/SIRT3/FOXO1 Levels
by: Zoltan Gombos, et al.
Published: (2021-07-01)

Depigmenting Effect of Resveratrol Is Dependent on FOXO3a Activation without SIRT1 Activation
by: Soon-Hyo Kwon, et al.
Published: (2017-06-01)

Sirt7 promotes adipogenesis by binding to and inhibiting Sirt1
by: Smolka Christian, et al.
Published: (2012-06-01)