Systematic detection of functional proteoform groups from bottom-up proteomic datasets

Many proteins exist in various proteoforms but detecting these variants by bottom-up proteomics remains difficult. Here, the authors present a computational approach based on peptide correlation analysis to identify and characterize proteoforms from bottom-up proteomics data.

Bibliographic Details
Main Authors: Isabell Bludau, Max Frank, Christian Dörig, Yujia Cai, Moritz Heusel, George Rosenberger, Paola Picotti, Ben C. Collins, Hannes Röst, Ruedi Aebersold
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24030-x

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