Clinical and visual outcomes of patients with uveitis in the mid-Atlantic United States

Asima Bajwa,1 Chang Sup Lee,1 Jim Patrie,2 Wenjun Xin,2 Ashvini K Reddy1 1Department of Ophthalmology, 2Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA Purpose: To report the clinical outcomes of uveitis patients at the University of Virginia. Methods: Retros...

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Main Authors: Bajwa A, Lee CS, Patrie J, Xin W, Reddy AK
Format: Article
Language:English
Published: Dove Medical Press 2015-09-01
Series:Clinical Ophthalmology
Online Access:https://www.dovepress.com/clinical-and-visual-outcomes-of-patients-with-uveitis-in-the-mid-atlan-peer-reviewed-article-OPTH
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spelling doaj-4bb51c5fd8134ce5a3aa0b5ec15bbfcb2020-11-25T00:41:17ZengDove Medical PressClinical Ophthalmology1177-54832015-09-012015default1655166423572Clinical and visual outcomes of patients with uveitis in the mid-Atlantic United StatesBajwa ALee CSPatrie JXin WReddy AKAsima Bajwa,1 Chang Sup Lee,1 Jim Patrie,2 Wenjun Xin,2 Ashvini K Reddy1 1Department of Ophthalmology, 2Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA Purpose: To report the clinical outcomes of uveitis patients at the University of Virginia. Methods: Retrospective, observational study of uveitis patients seen at the University of Virginia from 1984 to 2014. Parametric and nonparametric methods were used to analyze the change in best-corrected visual acuity (BCVA) in relation to demographics, diagnoses, management, and complications. Results: The study included 644 eyes of 491 patients. Patients with mild visual loss (logMAR <0.4) at presentation were younger than those with severe visual loss (SVL, logMAR >1.0) (P=0.002). Females were more likely to have mild visual loss as compared to males (P=0.025). Median overall BCVA was logMAR 0.18 at initial and final presentation (P=1.00). Vision loss at diagnosis was a predictor for moderate visual loss (MVL, logMAR 0.4 to <1.0) to SVL at last follow-up (P<0.001). Eyes with ocular hypertension were positively associated with MVL and SVL as compared to normotensive eyes (1.89 times at baseline, 2.62 times at last follow-up). Median BCVA was 0.18 logMAR for the anterior uveitis (AU) and 0.48 logMAR for the non-AU patients (P<0.001). AU patients were less likely to have SVL than non-AU group (P<0.001). AU group received local corticosteroids more frequently and systemic corticosteroids less commonly than non-AU patients (P<0.001). AU patients with MVL to SVL were more likely to have ophthalmic surgery (cataract, glaucoma or pars plana vitrectomy [PPV]) than those without MVL or SVL (P<0.001). Non-AU patients with MVL to SVL were more likely to have PPV than those without MVL or SVL (P=0.001). Conclusion: Mean overall BCVA remained stable. Favorable visual results were associated with younger age, female gender, and AU. Poor visual prognosis was concomitant with SVL at presentation and ocular hypertension. Ocular surgery (cataract extraction and glaucoma filtration) was more frequently performed for AU patients with MVL to SVL than those AU patients who did not experience moderate to SVL. PPV was commonly performed for both AU and non-AU patients with MVL to SVL. Keywords: uveitis, visual outcome, best corrected visual acuity, clinical outcome, visual losshttps://www.dovepress.com/clinical-and-visual-outcomes-of-patients-with-uveitis-in-the-mid-atlan-peer-reviewed-article-OPTH
collection DOAJ
language English
format Article
sources DOAJ
author Bajwa A
Lee CS
Patrie J
Xin W
Reddy AK
spellingShingle Bajwa A
Lee CS
Patrie J
Xin W
Reddy AK
Clinical and visual outcomes of patients with uveitis in the mid-Atlantic United States
Clinical Ophthalmology
author_facet Bajwa A
Lee CS
Patrie J
Xin W
Reddy AK
author_sort Bajwa A
title Clinical and visual outcomes of patients with uveitis in the mid-Atlantic United States
title_short Clinical and visual outcomes of patients with uveitis in the mid-Atlantic United States
title_full Clinical and visual outcomes of patients with uveitis in the mid-Atlantic United States
title_fullStr Clinical and visual outcomes of patients with uveitis in the mid-Atlantic United States
title_full_unstemmed Clinical and visual outcomes of patients with uveitis in the mid-Atlantic United States
title_sort clinical and visual outcomes of patients with uveitis in the mid-atlantic united states
publisher Dove Medical Press
series Clinical Ophthalmology
issn 1177-5483
publishDate 2015-09-01
description Asima Bajwa,1 Chang Sup Lee,1 Jim Patrie,2 Wenjun Xin,2 Ashvini K Reddy1 1Department of Ophthalmology, 2Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA Purpose: To report the clinical outcomes of uveitis patients at the University of Virginia. Methods: Retrospective, observational study of uveitis patients seen at the University of Virginia from 1984 to 2014. Parametric and nonparametric methods were used to analyze the change in best-corrected visual acuity (BCVA) in relation to demographics, diagnoses, management, and complications. Results: The study included 644 eyes of 491 patients. Patients with mild visual loss (logMAR <0.4) at presentation were younger than those with severe visual loss (SVL, logMAR >1.0) (P=0.002). Females were more likely to have mild visual loss as compared to males (P=0.025). Median overall BCVA was logMAR 0.18 at initial and final presentation (P=1.00). Vision loss at diagnosis was a predictor for moderate visual loss (MVL, logMAR 0.4 to <1.0) to SVL at last follow-up (P<0.001). Eyes with ocular hypertension were positively associated with MVL and SVL as compared to normotensive eyes (1.89 times at baseline, 2.62 times at last follow-up). Median BCVA was 0.18 logMAR for the anterior uveitis (AU) and 0.48 logMAR for the non-AU patients (P<0.001). AU patients were less likely to have SVL than non-AU group (P<0.001). AU group received local corticosteroids more frequently and systemic corticosteroids less commonly than non-AU patients (P<0.001). AU patients with MVL to SVL were more likely to have ophthalmic surgery (cataract, glaucoma or pars plana vitrectomy [PPV]) than those without MVL or SVL (P<0.001). Non-AU patients with MVL to SVL were more likely to have PPV than those without MVL or SVL (P=0.001). Conclusion: Mean overall BCVA remained stable. Favorable visual results were associated with younger age, female gender, and AU. Poor visual prognosis was concomitant with SVL at presentation and ocular hypertension. Ocular surgery (cataract extraction and glaucoma filtration) was more frequently performed for AU patients with MVL to SVL than those AU patients who did not experience moderate to SVL. PPV was commonly performed for both AU and non-AU patients with MVL to SVL. Keywords: uveitis, visual outcome, best corrected visual acuity, clinical outcome, visual loss
url https://www.dovepress.com/clinical-and-visual-outcomes-of-patients-with-uveitis-in-the-mid-atlan-peer-reviewed-article-OPTH
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