γA gene repeats polymorphism for the analysis of haplotypes of abnormal hemoglobins

γA gene repeats polymorphism for the analysis of haplotypes of abnormal hemoglobins

Aim of this study was to analyze γ A gene repeat polymorphism for the analysis of haplotypes of hemoglobin (Hb) variants such as Hb S, Hb D-Punjab, Hb O-Arab. Sickle cell cases had mainly Benin and Arab/Indian haplotype. We found three different haplotypes among Hb S, Hb O Arab and Hb D-Punjab cases...

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Main Authors: Nejat Akar, Kadir Sipahi, Ece Akar, Erkan Yilmaz
Format: Article
Language:English
Published: PAGEPress Publications 2014-09-01
Series:Thalassemia Reports
Subjects:
hemoglobin, sickle cell disease, hemoglobin D-Punjab, repetitive sequence, Hb OArab, haplotype.
Online Access:http://www.pagepressjournals.org/index.php/thal/article/view/1935
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spelling doaj-4ba263327af84ea8962021c8522f91cd2020-11-25T03:19:02ZengPAGEPress PublicationsThalassemia Reports2039-43572039-43652014-09-014210.4081/thal.2014.19353877γA gene repeats polymorphism for the analysis of haplotypes of abnormal hemoglobinsNejat Akar0Kadir Sipahi1Ece Akar2Erkan Yilmaz3Department of Pediatric Molecular Genetics, Ankara University, AnkaraDepartment of Pediatric Molecular Genetics, Ankara University, AnkaraDepartment of Pediatric Molecular Genetics, Ankara University, AnkaraDepartment of Pediatric Molecular Genetics, Ankara University, AnkaraAim of this study was to analyze γ A gene repeat polymorphism for the analysis of haplotypes of hemoglobin (Hb) variants such as Hb S, Hb D-Punjab, Hb O-Arab. Sickle cell cases had mainly Benin and Arab/Indian haplotype. We found three different haplotypes among Hb S, Hb O Arab and Hb D-Punjab cases. We named these three variants as Anatolian-1 and Anatolian-2 and Asian. Our data revealed that Hb O Arab may arise twice one from Asia and the other from Europe.http://www.pagepressjournals.org/index.php/thal/article/view/1935hemoglobin, sickle cell disease, hemoglobin D-Punjab, repetitive sequence, Hb OArab, haplotype.
collection DOAJ
language English
format Article
sources DOAJ
author Nejat Akar
Kadir Sipahi
Ece Akar
Erkan Yilmaz
spellingShingle Nejat Akar
Kadir Sipahi
Ece Akar
Erkan Yilmaz
γA gene repeats polymorphism for the analysis of haplotypes of abnormal hemoglobins
Thalassemia Reports
hemoglobin, sickle cell disease, hemoglobin D-Punjab, repetitive sequence, Hb OArab, haplotype.
author_facet Nejat Akar
Kadir Sipahi
Ece Akar
Erkan Yilmaz
author_sort Nejat Akar
title γA gene repeats polymorphism for the analysis of haplotypes of abnormal hemoglobins
title_short γA gene repeats polymorphism for the analysis of haplotypes of abnormal hemoglobins
title_full γA gene repeats polymorphism for the analysis of haplotypes of abnormal hemoglobins
title_fullStr γA gene repeats polymorphism for the analysis of haplotypes of abnormal hemoglobins
title_full_unstemmed γA gene repeats polymorphism for the analysis of haplotypes of abnormal hemoglobins
title_sort γa gene repeats polymorphism for the analysis of haplotypes of abnormal hemoglobins
publisher PAGEPress Publications
series Thalassemia Reports
issn 2039-4357
2039-4365
publishDate 2014-09-01
description Aim of this study was to analyze γ A gene repeat polymorphism for the analysis of haplotypes of hemoglobin (Hb) variants such as Hb S, Hb D-Punjab, Hb O-Arab. Sickle cell cases had mainly Benin and Arab/Indian haplotype. We found three different haplotypes among Hb S, Hb O Arab and Hb D-Punjab cases. We named these three variants as Anatolian-1 and Anatolian-2 and Asian. Our data revealed that Hb O Arab may arise twice one from Asia and the other from Europe.
topic hemoglobin, sickle cell disease, hemoglobin D-Punjab, repetitive sequence, Hb OArab, haplotype.
url http://www.pagepressjournals.org/index.php/thal/article/view/1935
work_keys_str_mv AT nejatakar gagenerepeatspolymorphismfortheanalysisofhaplotypesofabnormalhemoglobins
AT kadirsipahi gagenerepeatspolymorphismfortheanalysisofhaplotypesofabnormalhemoglobins
AT eceakar gagenerepeatspolymorphismfortheanalysisofhaplotypesofabnormalhemoglobins
AT erkanyilmaz gagenerepeatspolymorphismfortheanalysisofhaplotypesofabnormalhemoglobins
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