Humanin Attenuates NMDA-Induced Excitotoxicity by Inhibiting ROS-dependent JNK/p38 MAPK Pathway

Humanin Attenuates NMDA-Induced Excitotoxicity by Inhibiting ROS-dependent JNK/p38 MAPK Pathway

Humanin (HN) is a novel 24-amino acid peptide that protects neurons against N-methyl-d-aspartate (NMDA)-induced toxicity. However, the contribution of the different mitogen-activated protein kinases (MAPKs) signals to HN neuroprotection against NMDA neurotoxicity remains unclear. The present study w...

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Bibliographic Details
Main Authors: Xiaorong Yang, Hongmei Zhang, Jinzi Wu, Litian Yin, Liang-Jun Yan, Ce Zhang
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:International Journal of Molecular Sciences
Subjects:
HN
neuroprotection
NMDA
excitotoxicity
MAPKs
ROS
Online Access:http://www.mdpi.com/1422-0067/19/10/2982

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