Effect of IL-1 and gustducin expression change on bitter taste during fever
<span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>Homeostatic changes in the body, such as fever, cause inflammation, whose one of its impacts is the sense of bitterness inside the </em><span style=...
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| Format: | Article |
| Language: | English |
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Universitas Airlangga
2008-06-01
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| Series: | Dental Journal: Majalah Kedokteran Gigi |
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| Online Access: | http://e-journal.unair.ac.id/index.php/MKG/article/view/1016 |
| Summary: | <span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>Homeostatic changes in the body, such as fever, cause inflammation, whose one of its impacts is the sense of bitterness inside the </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>mouth. It implies in the reduction of appetite, which may finally result in the reduction of physical condition due to the inadequacy </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>of food intake. It causes the inhibition of healing process, which reduces working productivity. The objective of this study was to </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>identify the mechanism of bitterness due to inflammation, as proved locally in the taste buds of Wistar rats. This study was carried </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>out experimentally using post-test only control design in experimental animals of male Wistar strain Rattus norvegicus. The animals </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>were divided into two groups. First group served as control, while the second group received treatment with Salmonella typhimurium </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>0.5 ml/kg BW. Blood sample and tongue incision were taken from the animals. IL-1 was counted, and tongue incision was used for </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>immunohistochemical staining for the variables of gustducin. Data were analyzed using Kolmogorov-Smirnov test for data normality, </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>and followed with comparative test. The discriminant analysis was also done to find the discriminant variable. It was found that there </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>was an increase of biological response of signaling transduction of bitterness in taste buds, as indicated from the increase of gustducin </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>in treatment group or in inflammatory fever condition as compared to control group (p < 0.05), but no change of concertation at IL-1 </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>significan whenever there was any change of concertation by unfolding its mechanism. Further studies can be recommended to find the </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>way to inhibit this sense of bitterness. The results are intended to overcome homeostatic disorder in the body to prevent loss of appetite, </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>so that physical endurance can be maintained. It concluded that there is no increase of serum IL-1 expression in fever, but there is a </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>significanly increase of taste buds gustducin. Further studies should focus on gustducin cellular role in other factors that play a role </em><span style="font-family: Tribune-Italic; font-size: 9pt; color: #231f20; font-style: normal; font-variant: normal;"><em>in taste buds signal transduction, either in homeostatic condition or in the condition of homeostatic disorder.</em></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span><br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;" /></span> |
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| ISSN: | 1978-3728 2442-9740 |