Physical activity prevents acute inflammation in a gout model by downregulation of TLR2 on circulating neutrophils as well as inhibition of serum CXCL1 and is associated with decreased pain and inflammation in gout patients

Physical activity prevents acute inflammation in a gout model by downregulation of TLR2 on circulating neutrophils as well as inhibition of serum CXCL1 and is associated with decreased pain and inflammation in gout patients

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Objectives Gout is the most prevalent inflammatory arthritis. To study the effects of regular physical activity and exercise intensity on inflammation and clinical outcome, we examined inflammatory pathogenesis in an acute model of murine gout and analyzed human gout patient clinical data as a funct...

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Main Authors: Kyle Jablonski, Nicholas A. Young, Caitlin Henry, Kyle Caution, Anuradha Kalyanasundaram, Ifeoma Okafor, Peter Harb, Emmy Schwarz, Paul Consiglio, Chris M. Cirimotich, Anna Bratasz, Anasuya Sarkar, Amal O. Amer, Wael N. Jarjour, Naomi Schlesinger, Fulvio D'Acquisto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529261/?tool=EBI

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