The Two Isoforms of Lyn Display Different Intramolecular Fuzzy Complexes with the SH3 Domain

The Two Isoforms of Lyn Display Different Intramolecular Fuzzy Complexes with the SH3 Domain

The function of the intrinsically disordered Unique domain of the Src family of tyrosine kinases (SFK), where the largest differences between family members are concentrated, remains poorly understood. Recent studies in c-Src have demonstrated that the Unique region forms transient interactions, des...

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Bibliographic Details
Main Authors: João M. C. Teixeira, Héctor Fuentes, Stasė Bielskutė, Margarida Gairi, Szymon Żerko, Wiktor Koźmiński, Miquel Pons
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Molecules
Subjects:
Src family kinases
Src
Lyn
SH3 domains
intrinsically disordered proteins
fuzzy complexes
SFKs unique domains
nuclear magnetic resonance
Farseer-NMR
Online Access:https://www.mdpi.com/1420-3049/23/11/2731

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