Optogenetic translocation of protons out of penumbral neurons is protective in a rodent model of focal cerebral ischemia

Background: Intracellular acidosis in the ischemic penumbra can contribute to further cell death, effectively enlarging the infarct core. Restoring the acid-base balance may enhance tissue survivability after cerebral ischemia. Objective: This study investigated whether translocating protons out of...

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Bibliographic Details
Main Authors: Bin Bo, Yao Li, Wanlu Li, Yongting Wang, Shanbao Tong
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Brain Stimulation
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1935861X20300619