Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.

Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.

Kidneys age at different rates, such that some people show little or no effects of aging whereas others show rapid functional decline. We sequentially used transcriptional profiling and expression quantitative trait loci (eQTL) mapping to narrow down which genes to test for association with kidney a...

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Bibliographic Details
Main Authors: Heather E Wheeler, E Jeffrey Metter, Toshiko Tanaka, Devin Absher, John Higgins, Jacob M Zahn, Julie Wilhelmy, Ronald W Davis, Andrew Singleton, Richard M Myers, Luigi Ferrucci, Stuart K Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-10-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2752811?pdf=render

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