A novel phosphoramide compound, DCZ0805, shows potent anti-myeloma activity via the NF-κB pathway

A novel phosphoramide compound, DCZ0805, shows potent anti-myeloma activity via the NF-κB pathway

Abstract Background Multiple myeloma (MM) is a highly aggressive and incurable clonal plasma cell disease with a high rate of recurrence. Thus, the development of new therapies is urgently needed. DCZ0805, a novel compound synthesized from osalmide and pterostilbene, has few observed side effects. I...

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Bibliographic Details
Main Authors: Xuejie Gao, Bo Li, Anqi Ye, Houcai Wang, Yongsheng Xie, Dandan Yu, Zhijian Xu, Bingqing Shi, Hui Zhang, Qilin Feng, Ke Hu, Yong Zhang, Cheng Huang, Guang Yang, Jumei Shi, Weiliang Zhu
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Cancer Cell International
Subjects:
Multiple myeloma
Anti-tumor activity
NF-κB
Online Access:https://doi.org/10.1186/s12935-021-01973-1

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