Continuous Flow Esterification of a <i>H</i>-Phosphinic Acid, and Transesterification of <i>H</i>-Phosphinates and <i>H</i>-Phosphonates under Microwave Conditions

Continuous Flow Esterification of a <i>H</i>-Phosphinic Acid, and Transesterification of <i>H</i>-Phosphinates and <i>H</i>-Phosphonates under Microwave Conditions

The microwave (MW)-assisted direct esterification of phenyl-<i>H</i>-phosphinic acid, transesterification of the alkyl phenyl-<i>H</i>-phosphinates so obtained, and the similar reaction of dibenzyl phosphite (DBP) were investigated in detail, and the batch accomplishments wer...

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Main Authors: Nóra Zsuzsa Kiss, Réka Henyecz, György Keglevich
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Molecules
Subjects:
<i>h</i>-phosphinic acid
esterification
<i>h</i>-phosphinates
<i>h</i>-phosphonates
transesterification
microwave flow reactor
Online Access:https://www.mdpi.com/1420-3049/25/3/719
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spelling doaj-4b694a4b17f2482ba0a8a8b028e24def2020-11-25T02:20:24ZengMDPI AGMolecules1420-30492020-02-0125371910.3390/molecules25030719molecules25030719Continuous Flow Esterification of a <i>H</i>-Phosphinic Acid, and Transesterification of <i>H</i>-Phosphinates and <i>H</i>-Phosphonates under Microwave ConditionsNóra Zsuzsa Kiss0Réka Henyecz1György Keglevich2Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1111 Budapest, HungaryDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1111 Budapest, HungaryDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1111 Budapest, HungaryThe microwave (MW)-assisted direct esterification of phenyl-<i>H</i>-phosphinic acid, transesterification of the alkyl phenyl-<i>H</i>-phosphinates so obtained, and the similar reaction of dibenzyl phosphite (DBP) were investigated in detail, and the batch accomplishments were translated into a continuous flow operation that, after optimization of the parameters, such as temperature and flow rate, proved to be more productive. Alcoholysis of DBP is a two-step process involving an intermediate phosphite with two different alkoxy groups. The latter species are of synthetic interest, as precursors for optically active reagents.https://www.mdpi.com/1420-3049/25/3/719<i>h</i>-phosphinic acidesterification<i>h</i>-phosphinates<i>h</i>-phosphonatestransesterificationmicrowave flow reactor
collection DOAJ
language English
format Article
sources DOAJ
author Nóra Zsuzsa Kiss
Réka Henyecz
György Keglevich
spellingShingle Nóra Zsuzsa Kiss
Réka Henyecz
György Keglevich
Continuous Flow Esterification of a <i>H</i>-Phosphinic Acid, and Transesterification of <i>H</i>-Phosphinates and <i>H</i>-Phosphonates under Microwave Conditions
Molecules
<i>h</i>-phosphinic acid
esterification
<i>h</i>-phosphinates
<i>h</i>-phosphonates
transesterification
microwave flow reactor
author_facet Nóra Zsuzsa Kiss
Réka Henyecz
György Keglevich
author_sort Nóra Zsuzsa Kiss
title Continuous Flow Esterification of a <i>H</i>-Phosphinic Acid, and Transesterification of <i>H</i>-Phosphinates and <i>H</i>-Phosphonates under Microwave Conditions
title_short Continuous Flow Esterification of a <i>H</i>-Phosphinic Acid, and Transesterification of <i>H</i>-Phosphinates and <i>H</i>-Phosphonates under Microwave Conditions
title_full Continuous Flow Esterification of a <i>H</i>-Phosphinic Acid, and Transesterification of <i>H</i>-Phosphinates and <i>H</i>-Phosphonates under Microwave Conditions
title_fullStr Continuous Flow Esterification of a <i>H</i>-Phosphinic Acid, and Transesterification of <i>H</i>-Phosphinates and <i>H</i>-Phosphonates under Microwave Conditions
title_full_unstemmed Continuous Flow Esterification of a <i>H</i>-Phosphinic Acid, and Transesterification of <i>H</i>-Phosphinates and <i>H</i>-Phosphonates under Microwave Conditions
title_sort continuous flow esterification of a <i>h</i>-phosphinic acid, and transesterification of <i>h</i>-phosphinates and <i>h</i>-phosphonates under microwave conditions
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2020-02-01
description The microwave (MW)-assisted direct esterification of phenyl-<i>H</i>-phosphinic acid, transesterification of the alkyl phenyl-<i>H</i>-phosphinates so obtained, and the similar reaction of dibenzyl phosphite (DBP) were investigated in detail, and the batch accomplishments were translated into a continuous flow operation that, after optimization of the parameters, such as temperature and flow rate, proved to be more productive. Alcoholysis of DBP is a two-step process involving an intermediate phosphite with two different alkoxy groups. The latter species are of synthetic interest, as precursors for optically active reagents.
topic <i>h</i>-phosphinic acid
esterification
<i>h</i>-phosphinates
<i>h</i>-phosphonates
transesterification
microwave flow reactor
url https://www.mdpi.com/1420-3049/25/3/719
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AT rekahenyecz continuousflowesterificationofaihiphosphinicacidandtransesterificationofihiphosphinatesandihiphosphonatesundermicrowaveconditions
AT gyorgykeglevich continuousflowesterificationofaihiphosphinicacidandtransesterificationofihiphosphinatesandihiphosphonatesundermicrowaveconditions
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