Fibroblast growth factor 2 is necessary for the antidepressant effects of fluoxetine.

Previous research has shown that fibroblast growth factor 2 protein (FGF2) can act as an anxiolytic and anti-depressive agent in rodents. Levels of hippocampal FGF2 and FGF2 receptors are decreased in post-mortem brains of individuals with mood disorders. No changes in FGF2 were noted in the post-mo...

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Bibliographic Details
Main Authors: Stephanie Simard, Pragya Shail, Jessica MacGregor, Maha El Sayed, Ronald S Duman, Flora M Vaccarino, Natalina Salmaso
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6166983?pdf=render