Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock

The effect of the liver clock is modified by food entrainment via Bmal1/Clock core machinery. Here the authors show that insulin promotes postprandial Akt-dependent phosphorylation of Bmal1, resulting in association with 14-3-3 and Bmal1 shuttling out of the nucleus, thereby disrupting Bmal1 transcr...

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Main Authors:	Fabin Dang, Xiujie Sun, Xiang Ma, Rong Wu, Deyi Zhang, Yaqiong Chen, Qian Xu, Yuting Wu, Yi Liu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms12696

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spelling	doaj-4b62ffc0e73f45a1a3e2a6fa147df23e2021-05-11T10:52:15ZengNature Publishing GroupNature Communications2041-17232016-08-017111210.1038/ncomms12696Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clockFabin Dang0Xiujie Sun1Xiang Ma2Rong Wu3Deyi Zhang4Yaqiong Chen5Qian Xu6Yuting Wu7Yi Liu8Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesDepartment of Endocrinology, The First Affiliated Hospital of Harbin Medical UniversityKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesThe effect of the liver clock is modified by food entrainment via Bmal1/Clock core machinery. Here the authors show that insulin promotes postprandial Akt-dependent phosphorylation of Bmal1, resulting in association with 14-3-3 and Bmal1 shuttling out of the nucleus, thereby disrupting Bmal1 transcriptional effects on the clock.https://doi.org/10.1038/ncomms12696
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Fabin Dang Xiujie Sun Xiang Ma Rong Wu Deyi Zhang Yaqiong Chen Qian Xu Yuting Wu Yi Liu
spellingShingle	Fabin Dang Xiujie Sun Xiang Ma Rong Wu Deyi Zhang Yaqiong Chen Qian Xu Yuting Wu Yi Liu Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock Nature Communications
author_facet	Fabin Dang Xiujie Sun Xiang Ma Rong Wu Deyi Zhang Yaqiong Chen Qian Xu Yuting Wu Yi Liu
author_sort	Fabin Dang
title	Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock
title_short	Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock
title_full	Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock
title_fullStr	Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock
title_full_unstemmed	Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock
title_sort	insulin post-transcriptionally modulates bmal1 protein to affect the hepatic circadian clock
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-08-01
description	The effect of the liver clock is modified by food entrainment via Bmal1/Clock core machinery. Here the authors show that insulin promotes postprandial Akt-dependent phosphorylation of Bmal1, resulting in association with 14-3-3 and Bmal1 shuttling out of the nucleus, thereby disrupting Bmal1 transcriptional effects on the clock.
url	https://doi.org/10.1038/ncomms12696
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Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock

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