Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock

Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock

The effect of the liver clock is modified by food entrainment via Bmal1/Clock core machinery. Here the authors show that insulin promotes postprandial Akt-dependent phosphorylation of Bmal1, resulting in association with 14-3-3 and Bmal1 shuttling out of the nucleus, thereby disrupting Bmal1 transcr...

Full description

Bibliographic Details
Main Authors: Fabin Dang, Xiujie Sun, Xiang Ma, Rong Wu, Deyi Zhang, Yaqiong Chen, Qian Xu, Yuting Wu, Yi Liu
Format: Article
Language:English
Published: Nature Publishing Group 2016-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12696
Description
Summary:The effect of the liver clock is modified by food entrainment via Bmal1/Clock core machinery. Here the authors show that insulin promotes postprandial Akt-dependent phosphorylation of Bmal1, resulting in association with 14-3-3 and Bmal1 shuttling out of the nucleus, thereby disrupting Bmal1 transcriptional effects on the clock.
ISSN:2041-1723

Similar Items