Targeting Smoothened as a New Frontier in the Functional Recovery of Central Nervous System Demyelinating Pathologies

Targeting Smoothened as a New Frontier in the Functional Recovery of Central Nervous System Demyelinating Pathologies

Myelin sheaths on vertebrate axons provide protection, vital support and increase the speed of neuronal signals. Myelin degeneration can be caused by viral, autoimmune or genetic diseases. Remyelination is a natural process that restores the myelin sheath and, consequently, neuronal function after a...

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Bibliographic Details
Main Authors:	Alice Del Giovane, Antonella Ragnini-Wilson
Format:	Article
Language:	English
Published:	MDPI AG 2018-11-01
Series:	International Journal of Molecular Sciences
Subjects:	remyelination oligodendrocytes drug screening smoothened agonists
Online Access:	https://www.mdpi.com/1422-0067/19/11/3677

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