The TAK1→IKKβ→TPL2→MKK1/MKK2 signaling cascade regulates IL-33 expression in Cystic Fibrosis airway epithelial cells following infection by Pseudomonas aeruginosa

The TAK1→IKKβ→TPL2→MKK1/MKK2 signaling cascade regulates IL-33 expression in Cystic Fibrosis airway epithelial cells following infection by Pseudomonas aeruginosa

In cystic fibrosis (CF), chronic respiratory infections result in an exaggerated and uncontrolled inflammatory response that ultimately lead to a decrease in pulmonary function. We have previously described the presence of the alarmin IL-33 in lung explants from CF patients. The signals regulating I...

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Bibliographic Details
Main Authors: Raquel eFarias, Simon eRousseau
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Pseudomonas aeruginosa
Toll-Like Receptors
ERK
MAPK
Airway epithelium
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00087/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00087/full

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