Functional Change of Effector Tumor-Infiltrating CCR5+CD38+HLA-DR+CD8+ T Cells in Glioma Microenvironment

Functional Change of Effector Tumor-Infiltrating CCR5+CD38+HLA-DR+CD8+ T Cells in Glioma Microenvironment

Human glioma facilitates an impaired anti-tumor immunity response, including defects in circulation of T lymphocytes. The level of CD8+ T-cell activation acts as an immune regulator associated with disease progression. However, little is known about the characteristics of peripheral and tumor-infilt...

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Bibliographic Details
Main Authors: Pin-Yuan Chen, Caren Yu-Ju Wu, Jian-He Fang, Hsiu-Chi Chen, Li-Ying Feng, Chiung-Yin Huang, Kuo-Chen Wei, Jia-You Fang, Chun-Yen Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
glioma
CD8
T cell
CCL5
CCR5
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02395/full

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