Antioxidant, Anti-inflammatory and Neuroprotective Profiles of Novel 1,4-Dihydropyridine Derivatives for the Treatment of Alzheimer’s Disease

Antioxidant, Anti-inflammatory and Neuroprotective Profiles of Novel 1,4-Dihydropyridine Derivatives for the Treatment of Alzheimer’s Disease

Alzheimer’s disease is a chronic and irreversible pathological process that has become the most prevalent neurodegenerative disease. Currently, it is considered a multifactorial disease where oxidative stress and chronic neuroinflammation play a crucial role in its onset and development. Its charact...

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Bibliographic Details
Main Authors: Patrycja Michalska, Paloma Mayo, Cristina Fernández-Mendívil, Giammarco Tenti, Pablo Duarte, Izaskun Buendia, María Teresa Ramos, Manuela G. López, J. Carlos Menéndez, Rafael León
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Antioxidants
Subjects:
Alzheimer’s disease
multitarget drugs
4,7-dihydro-2<i>H</i>-pyrazolo[3,4-<i>b</i>]pyridines GSK‑3β inhibitors
voltage gated calcium channels antagonists
anti-inflammatory drugs
neuroprotection
Online Access:https://www.mdpi.com/2076-3921/9/8/650

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https://www.mdpi.com/2076-3921/9/8/650

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